2,3 Recognised autosomal dominant mutations within sarcomere proteins are found in 55 % of adolescents with sporadic HCM. The disease has complex symptomatology and potentially devastating consequences for … INTRODUCTION. Summary. And they’re ready for you to use in your PowerPoint presentations the moment you need them. Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. ... Cardiomyopathy Pathophysiology. The parts of the heart most commonly affected are the interventricular septum and the ventricles. Cardiomyopathies are diseases of the muscle tissue of the heart.Types of cardiomyopathies include dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular cardiomyopathy. Luis Fuentes V, Wilkie L J (2017) Asymptomative hypertrophic cardiomyopathy: Diagnosis and therapy. Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. Cardiomyopathies are diseases of the muscle tissue of the heart.Types of cardiomyopathies include dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular cardiomyopathy. Hypertrophic cardiomyopathy. However, unlike the type above, the thickened area causes an obstruction that affects the flow of blood leaving the heart. Clipping is a handy way to collect important slides you want to go back to later. The septal artery catheter balloon is inflated preventing backwash of alcohol into the remainder of the coronary tree. Introduction. Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. Cardiology Grand Rounds from the University of Texas Medical Branch Hypertrophic Cardiomyopathy: Presentation and Pathophysiology Marschall S. Runge, MD George A. Stouffer, MD * Richard G. Sheahan, MD Stamatios Lerakis, MD From the Division of Cardiology, Department of Medicine, The University of Texas Medical Branch, Galveston, Texas. They are all artistically enhanced with visually stunning color, shadow and lighting effects. It is commonly asymmetrical with the most severe hypertrophy involving the basal interventricular septum. Ommen, SR et al. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Causes of sudden cardiac death in young people Myocarditis 3% Maron BJ et al. Evaluation and Testing for HCM. Classification and Definitions of Cardiomyopathies 9 3.1. XXX:XX-XX. MAIN TYPES OF CARDIOMYOPATHY Hypertrophic Cardiomyopathy: Hypertrophy means ‘increase in size.’ It is the increase in size of the heart muscle. 16. The main pathophysiology behind is that every organ is in homeostasis with physiological stress. HCM is an inherited (autosomal dominant) disease of the myocardium. Colors correspond to the Class of Recommendation The ventricle size often remains normal, but the thickening may block blood flow out of the ventricle. Takotsubotype cardiomyopathy due to multivesselspasm. Images. Case17 years old male professional basketball player with noknown past medical history collapses on the playing floorduring practice and subsequently arrests. ... Cardiomyopathy Pathophysiology. It's FREE! In other instances, the cause is unknown. See our Privacy Policy and User Agreement for details. The thickened heart muscle can make it harder for the heart to pump blood.Hypertrophic cardiomyopathy often goes undiagnosed because many people with the disease have few, if any, symptoms and can lead normal lives with no significant problems. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. What Causes Hypertrophic Cardiomyopathy? Adapted from Spirito, P. et al. Evaluation and Testing for HCM. This results in the heart being less able to pump blood effectively and also may cause electrical conduction problems.. People who have HCM may have a range of symptoms. Hypertrophic cardiomyopathy (HCM) is a disease in which the heart muscle (myocardium) becomes abnormally thick (hypertrophied). Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. Increased voltages c/w left ventricular hypertrophy Repolarization changes Q waves = not ischemia – reflect anterior septal thickness, Decreased projection of basal septum into the LVOT, Gold standard for pts w/ drug-refractory HCM Resect a small portion of myocardium from septum – enlarges LVOT and relieves obstruction; also causes concomitant mitral regurg to disappear Operative mortality: <1% Complications rare (heart block, VSD, aortic regurg). Etiology of Hypertrophic Cardiomyopathy is mostly due to: - 1. HCM, which occurs in 0.2% of the general population, is the most common cause of sudden cardiac death in young people. 22: Figure 1. Additionally, the report provides an overview of key players involved in therapeutic development for Hypertrophic Cardiomyopathy and features dormant and discontinued projects. If so, share your PPT presentation slides online with PowerShow.com. N Engl J Med. MAIN TYPES OF CARDIOMYOPATHY Hypertrophic Cardiomyopathy: Hypertrophy means ‘increase in size.’ It is the increase in size of the heart muscle. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, representing a leading cause of sudden cardiac death in the young and a prevalent cause of heart failure and stroke. Cardiomyopathy: Pathophysiology and Assessment RobertoMLang,MD Circ J 2004; 68: 77-81 Japanese word for octopus catcher Tako-Tsubo Cardiomyopathy Broken Heart Syndrome Apical Balooning 1. INHibition of the renin angiotensin system in hypertrophic cardiomyopathy and the Effect on hypertrophy, - INHibition of the renin angiotensin system in hypertrophic cardiomyopathy and the Effect on hypertrophy a Randomized Intervention Trial with losartan. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. - Hypertrophic cardiomyopathy Frank and Mehta Non-Surgical Septal Ablation Echocardiographic still frames (systole) from the parasternal long-axis. CARDIOMYOPATHY BY: RICHARD KAMINSKI DESCRIPTION OF DISEASE • Hypertrophic cardiomyopathy (HCM) occurs if heart muscle cells enlarge and cause the walls of the ventricles (usually the left ventricle) to thicken. Hypertrophic cardiomyopathy is a primarily genetic condition affecting the sarcomeric proteins. Early Detection of Hypertrophic Cardiomyopathy, - Title: Slide 1 Author: mwiegand Last modified by: June Hanks Created Date: 4/15/2008 10:37:56 PM Document presentation format: On-screen Show (4:3) Company. When this happens, the ventricle has to work harder to pump out blood. If you continue browsing the site, you agree to the use of cookies on this website. It is commonly asymmetrical … Cardiomyopathy is any structural and functional abnormality of the heart muscle unattributable to specific causes or disease processes such as coronary artery disease (CAD), congenital heart disease, or valvular disease. In other instances, the cause is unknown. Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. The mitral valve can also be affected and is unable to close properly. 1. - ... Hypertrophy: in any region of left ventricle SAM: systolic anterior motion of anterior MV leaflet against hypertrophic septum (Bernoulli effect) ... - Cardiomyopathy Dr.mirdamadi Cardiologist, fellowship of echocardiograpy Apical HCM Apical hypertrophy Giant negative T wave on the ECG Spade shaped LV cavity ... - Dilated cardiomyopathy or DCM is a condition in which the heart becomes weakened and enlarged and cannot pump blood efficiently. the diagnosis, characterize the pathophysiology for the individual, and identify risk markers that may inform decisions regarding interventions ... *HCM indicates hypertrophic cardiomyopathy . Change in stress leads to adaptations. HCM can run in families, but the condition may also be acquired as a part of aging or high blood pressure. INTRODUCTION. In: Kodama K, Haze, K, Hon M, editors. - Myocyte 'disarray' 2/2 sarcomere mutations causes LV hypertrophy, usually with ... hypertrophic subaortic stenosis) and ASH (Asymmetric septal hypertrophy) are ... - Hypertrophic Cardiomyopathy Board Review Rami Khouzam, MD Hypertrophic Cardiomyopathy Definition: WHO: left and/or right ventricular hypertrophy, usually asymmetric ... Heart Muscle Disease (Cardiomyopathy) (1). - Famous for being leading cause of sudden cardiac death in young athletes ... Enlarged septum narrows left ventricle outflow tract. Circulation. REFERENCES. Clinical aspect of myocardial The report also covers the descriptive pharmacological action … Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course, for which several disease-causing mutations in genes encoding proteins of the sarcomere have been reported.1–7 Because of the characteristic clinical, morphological, and genetic diversity, HCM has held the curiosity … Initial clinical and hemodynamic evaluation suggested cardiogenic shock in two cases, acute myocardial ischemia in two cases, and hypovolemia in one case. ... An 80-year-old African-American woman is admitted to the hospital under your ... - Hypertrophic Cardiomyopathy Board Review Rami Khouzam, MD ... Congestive dilated cardiomyopathy. ... - Cardiomyopathy in neonates and children Dr Rajesh Kumar MD (PGI), DM (Neonatology) PGI, Chandigarh, India Rani Children Hospital, Ranchi Some cardiomyopathies are ... Clinical sensitivity of molecular genetic testing in hypertrophic cardiomyopathy. Summary. Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. Vet Clin North Am Small Anim Pract 47 (5), 1041-1054 PubMed . Up to 60% of the cases are due to mutations in - The research team projects that the Hypertrophic Cardiomyopathy (HCM) Therapeutics market size will grow from XXX in 2019 to XXX by 2026, at an estimated CAGR of XX. Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. See our User Agreement and Privacy Policy. Hypertrophic cardiomyopathy (HCM) is a condition in which the heart becomes thickened without an obvious cause. 1,2 It has a prevalence of 1 in 500 within the general population, and is a known cause of sudden cardiac death. Sequencing of the Hypertrophic Cardiomyopathy (HCM) genes using an automated high throughput strategy, - Sequencing of the Hypertrophic Cardiomyopathy (HCM) genes using an automated high throughput strategy Aisha Ansari Edinburgh Molecular Genetics. Hypertrophic Cardiomyopathy Dr. Fuad Farooq Resident CardiologyAga Khan University Hospital 2. Hypertrophic cardiomyopathy (HCM) is an intractable disease that causes heart failure mainly due to unexplained severe cardiac hypertrophy and diastolic dysfunction. CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. Long-term athletic training can produce “athlete’s heart” = increased LV diastolic cavity dimensions/wall thickness/mass. - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. The disease has complex symptomatology and potentially devastating consequences for … Atrial fibrillation (AF) is frequently associated with HCM with a reported prevalence of about 20% to 25%. Alcohol septal ablation. The two patients thought to be in cardiogenic shock were given inotropes … In the early stages of cardiomyopathy, there may be no symptoms at all. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. Spirito, P. et al. Initial clinical and hemodynamic evaluation suggested cardiogenic shock in two cases, acute myocardial ischemia in two cases, and hypovolemia in one case. It mainly manifests as symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle unexplained by other cardiac or systemic causes of hypertrophy (see Table 23–1 for differential diagnosis of LVH). 2020 ACC/AHA Guideline for the Diagnosis and Treatment of Patients with Hypertrophic Cardiomyopathy. Primary cardiomyopathies 3.1.1 Genetic 3.1.1.1 Hypertrophic cardiomyopathy HCM is a condition of the heart in … Many of them are also animated. 2020 ACC/AHA Guideline for the Diagnosis and Treatment of Patients with Hypertrophic Cardiomyopathy. Cardiomyopathy may be classified as being Primary, in which there is no attributable cause, or Secondary, in which the cardiomyopathy is due to a specific cause, such as hypertension, coronary artery disease, congenital heart disease, heart valve disease, viral infections etc. Hypertrophic cardiomyopathy (HCM) is defined by the presence of increased left ventricular (LV) wall thickness (for adults, >15 mm in one or more LV myocardial segments) that is not solely explained by abnormal loading conditions (eg hypertension). 1996;94:850-56. Questions? Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes which encode components of the contractile apparatus of the heart. Pathophysiology The two patients thought to be in cardiogenic shock were given inotropes … - Hypertrophic Cardiomyopathy (HCM) Therapeutics market report provides a brief and detailed knowledge of key reports, market conditions and circumstances. Cardiac hypertrophy is usually asymmetrical with greatest involvement most commonly of the basal interventricular septum subjacent to the aortic valve. In: Kodama K, Haze, K, Hon M, editors. Hypertrophic cardiomyopathy (HCM) has been defined morphologically by unexplained hypertrophy in the absence of haemodynamic stress, and at the histological level by myocyte disarray, fibrosis, and abnormalities of the intramyocardial small vessels. Hypertrophic cardiomyopathy (HCM) is defined as a primary cardiac muscle hypertrophy of the left ventricle in the absence of other structural or functional abnormality. XXX:XX-XX. Hypertrophic Cardiomyopathy Dr. Fuad Farooq Resident CardiologyAga Khan University Hospital. 22: Figure 1. PowerShow.com is a leading presentation/slideshow sharing website. The Global Therapeutic Landscape of Hypertrophic Cardiomyopathy - The report provides comprehensive information on the therapeutics under development for Hypertrophic Cardiomyopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. A J Marian (Jan 1, p 58)1 postulates that cardiac contractility is decreased in hypertrophic cardiomyopathy (HCM) and that the preserved or increased ejection fraction observed in patients with HCM is a result of the concentric nature of the hypertrophy. Circulation. Interrelations of clinical manifestations, pathophysiology and therapy (2). The main pathophysiology behind is that every organ is in homeostasis with physiological stress. Images. TM, 54, WAS ADMITTED to the ED after a syncopal episode that resulted in a head injury. D. Aortic stenosis. A J Marian (Jan 1, p 58)1 postulates that cardiac contractility is decreased in hypertrophic cardiomyopathy (HCM) and that the preserved or increased ejection fraction observed in patients with HCM is a result of the concentric nature of the hypertrophy. An introduction to hypertrophic cardiomyopathy (HCM). - Title: PowerPoint Presentation Author: Scott Johnson Last modified by: Authorised User Created Date: 3/10/2009 8:02:56 PM Document presentation format, Cardiomyopathy : Causes, Symptoms,Types, Diagnosis and Treatment (1). Hypertrophic cardiomyopathy (36%) Aortic stenosis 4% Congenital coronary anomalies (19%) Mildly increased cardiac mass (10%) Ruptured aorta … HYPERTROPHIC. HYPERTROPHIC. Genetic Etiology of Hypertrophic Cardiomyopathy (HCM) ~30-60% of HCM patients have an identifiable pathogenic or likely-pathogenic genetic variant Many others have no genetic evidence of disease and / or Causes of hypertrophic cardiomyopathy. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Clinical aspect of myocardial TM, 54, WAS ADMITTED to the ED after a syncopal episode that resulted in a head injury. Aetiology. Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease affecting 1 of every 500 persons (1, 2).Individuals with HCM are at an increased risk of heart failure and sudden cardiac death ().Usually, HCM is characterized by cardiac hypertrophy with preserved or increased ejection fraction (EF) and cardiac contractility in the absence of secondary causes. Genetic Etiology of Hypertrophic Cardiomyopathy (HCM) ~30-60% of HCM patients have an identifiable pathogenic or likely-pathogenic genetic variant Many others have no genetic evidence of disease and / or Introduction. Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder, affecting one of every 500 adults.It is found across all racial groups and is the most common cause of sudden death in young athletes ().The disease is characterized by left ventricular (LV) hypertrophy in the absence of another systemic or cardiac disease to account for the changes noted. The disease has complex symptomatology and potentially devastating consequences for … Takotsubotype cardiomyopathy due to multivesselspasm. Download a PDF version. Hypertrophic cardiomyopathy 1. Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes which encode components of the contractile apparatus of the heart. Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. However, the penetrance and expression of responsible genes vary, with complex presentations and sequela. This results in the heart being less able to pump blood effectively and also may cause electrical conduction problems.. People who have HCM may have a range of symptoms. presentations for free. Or use it to find and download high-quality how-to PowerPoint ppt presentations with illustrated or animated slides that will teach you how to do something new, also for free. This scarring leads to progressive thinning of the septum  outflow tract enlargement (mimicking LV remodeling that occurs after myectomy). the diagnosis, characterize the pathophysiology for the individual, and identify risk markers that may inform decisions regarding interventions ... *HCM indicates hypertrophic cardiomyopathy . 1 It is typically inherited via autosomal dominant pattern with mutations in cardiac sarcomere protein genes. Sato H, TateishiH, Uchida T, et al. Change in stress leads to adaptations. Atrial fibrillation (AF) is frequently associated with HCM with a reported prevalence of about 20% to 25%. Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course, for which several disease-causing mutations in genes encoding proteins of the sarcomere have been reported.1–7 Because of the characteristic clinical, morphological, and genetic diversity, HCM has held the curiosity … You can change your ad preferences anytime. Sato H, TateishiH, Uchida T, et al. Over the years, classification of this condition has been updated by the rapid advancement of genetic, imaging, and clinical investigation. In 2010, the Study Group on peripartum cardiomyopathy of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) defined PPCM as an idiopathic cardiomyopathy occurring towards the end of pregnancy or in the months following delivery, abortion or miscarriage, without other causes for heart failure, and with a left ventricular (LV) ejection fraction (EF) < 45% 5 (see Box). DISCUSSION: Hypertrophic cardiomyopathy(HCM) is a condition of the heart characterized by the thickening of the interventricular septum. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Circulation. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. Five patients, all women, age ranges 59 to 84 years, with underlying hypertrophic obstructive cardiomyopathy (HOCM) presented with profound hypotension. 1996;94:850-56. Cardiomyopathy Medication Market-Global Forecast to 2025. Do you have PowerPoint slides to share? It was first brought to attention by the British forensic pathologist Donald Teare in 1958 as a disease manifesting with symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle. Colors correspond to the Class of Recommendation Now customize the name of a clipboard to store your clips. DISCUSSION: Hypertrophic cardiomyopathy(HCM) is a condition of the heart characterized by the thickening of the interventricular septum. Primary cardiomyopathies 3.1.1 Genetic 3.1.1.1 Hypertrophic cardiomyopathy HCM is a condition of the heart in which a part of the myocardium or the muscle of the Ommen, SR et al. 3. Retrospective trial by a group at the Mayo Clinic Aim: Long-term effects of myectomy on survival Looked at mortality retrospectively among 3 groups from 1983-2001: 1) myectomy 2) LVOT obstruction w/o surgery 3) Non-obstructive HCM Mean follow-up: 6 yrs Compared to non-operative obstructive, myectomy patients had superior survival free from all-cause mortality / HCM-related mortality / sudden cardiac death. - Should be considered in: resting gradient 50 mmHg, or refractory to medical Rx. Powerpoint slides. Hogan DF, Fox P R, Jacob K et al (2015) Secondary prevention of cardiogenic arterial thromboembolism in the cat: The double-blind, randomized, positive-controlled feline arterial thromboembolism; clopidogrel vs. aspirin trial (FAT CAT). Introduction. The global Hypertrophic Cardiomyopathy (HCM) Therapeutics market explains the Hypertrophic Cardiomyopathy (HCM) Therapeutics market development trends, market size and large-scale industry situation to provide progressive approximation. - The report provides comprehensive information on the therapeutics under development for Hypertrophic Cardiomyopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. Cardiomyopathy: Pathophysiology and Assessment RobertoMLang,MD Circ J 2004; 68: 77-81 Japanese word for octopus catcher Tako-Tsubo Cardiomyopathy Broken Heart Syndrome Apical Balooning 1. What Causes Hypertrophic Cardiomyopathy?